SyMO-Chem is run by researchers and chemists from various backgrounds and with various functions. Projects are managed by experienced research chemists that have a PhD in organic, polymer or physical chemistry, while qualified technicians with expertise in different fields of chemistry and research are involved in the progress of projects. SyMO-Chem does not employ PhD students or post-docs. The director of SyMO-Chem BV is dr. ir. H. M. (Henk) Janssen.

SyMO-Chem BV has commissioners that advise the company. Prof.dr. E.W. (Bert) Meijer (from the Laboratory of Macromolecular and Organic Chemistry research group at the Eindhoven University of Technology, TU/e, the Netherlands) and prof. dr. Jos Put (former Science Director at DSM Research, the Netherlands) have a strong background in chemistry and science, while Sonja Vos-Poppelaars (TU/e Holding BV) has a background in finance and is the chairman of the board of comissioners.