Opportunities

SyMO-Chem has bought stocks of poly(propylene imine) dendrimers from DSM Research, and sells these dendrimers to clients in research sample quantities. The amine terminated PPI-dendrimers of generations 2, 3, 4 and 5 can be purchased, and typical quantities are 10G for generations 2 and 3, and 1G for generations 4 and 5. Costs for these typical quantities are EURO 250,-, EURO 400,-, EURO 125,- and EURO 200,-, respectively. Contact us, if you want to inquire for other quantities, and in case you want to order.

Disclaimer - Warranty

The PPI-materials are intended for research purposes only, not for drug, household or other use, and are being supplied to recipient with no warranties, express or implied, including any warranty of merchantibility or fitness for a particular purpose. To the extend permitted by law, SyMO-Chem BV shall not be liable for any loss, claim, damage, or liability, of whatsoever kind or nature, which may arise from or in connection with the use, handling or storage of this material.

General information on PPI-dendrimers

Poly(propylene imine) dendrimers have also been called Astramol dendrimers, or have been abbreviated simply as PPI-dendrimers, or as DAB-Am-x dendrimers. DAB stands for the diaminobutane core, and x = 4, 8, 16, 32 or 64 for the number of primary amine end groups associated with the generations 1, 2, 3, 4 or 5, respectively. Below, the molecular structure of the second generation (G2) amine terminated PPI-dendrimer (or DAB-Am-8) is shown. The next generation G3-material is produced by cyanoethylation and subsequent reduction of the resultant 16 nitrile end groups.

The molecular characteristics of the five existing generations of amine terminated poly(propylene imine) (PPI) dendrimers are given in the Table below.

Apart, from selling PPI-dendrimers in research sample quantities, SyMO-Chem can provide you with tailor-made dendrimers based on PPI-dendrimers, or can provide in contract research in the dendrimer chemistry field.

Background

Dendrimers are synthetic macromolecules with a well-defined, highly branched molecular structure that are synthesized in an algorithmic step-by-step fashion with every repeated sequence of reactions producing a higher generation (G) molecule that has a practically doubled molecular weight and a doubled (discrete) number of functional end-groups. Since 1985, numerous chemically different types of dendrimers have been developed, such as Tomalia’s poly (amido amino) PAMAM-dendrimers, Newkome’s arborols, Fréchet’s poly ether dendrimers, Meijer and Mülhaupt’s poly(propylene imine) PPI-dendrimers and Moore’s phenylacetylene dendrimers. Because of their defined structure, narrow polydispersity, defined nanoscale size and the ease of modification of the end groups, dendrimers are considered interesting candidates for various functions in life sciences and medicinal chemistry. For example, their function as binding-and-release agents in drug and gene delivery has been investigated.

The following review, and references therein, can be consulted to know more about dendrimers in general, and about PPI-dendrimers in particular: AW Bosman, HM Janssen, EW Meijer, ChemRev, 1999, 99, 1665-1688.